COMPARING REACTIVITY & STABILITY

Synhydrid® vs Sodium Borohydride

Download our whitepaper paper to discover advanced insights into the reactivity, stability, and solubility of Synhydrid® compared with metal hydride-reducing agents like Sodium Borohydride and Lithium Aluminium Hydride.

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Download this paper to discover advanced insights into the reactivity, stability, and solubility of Synhydrid® compared with metal hydride-reducing agents like Sodium Borohydride and Lithium Aluminium Hydride.

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Content Provided

• The paper compares Sodium Borohydride (NaBH₄) and Synhydrid® (sodium bis(2-methoxyethoxy) aluminumhydride) as reducing agents in organic synthesis.​
• It covers reactivity, selectivity, thermal stability, solubility, reaction conditions and applications.
• It highlights the limitations of Sodium Borohydride and Lithium Aluminium Hydride (LAH) as a reducing agent. Synhydrid® is introduced as a safer and more versatile alternative
• It concludes with outlining applications of Synhydrid® beyond reduction chemistry.

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Key Takeaways

Limited reduction scope of NaBH₄

Synhydrid® can reduce aldehydes, ketones, epoxides, acyl halides, anhydrides, carboxylic acids, esters, amides, nitriles, and imides.

Safety concerns with NaBH₄

Synhydrid® demonstrates greater safety due to its inherent stability and minimal risk of self-ignition upon exposure to moisture. ​

Difficulties in controlling reduction reactions with NaBH₄

Synhydrid® allows for selective reduction of target functional groups while minimising interference with others.

NaBH₄ is incompatible with certain solvents

Synhydrid® is highly soluble in ethers and aromatic hydrocarbons.

SYNHYDRID® VS SODIUM BOROHYDRIDE

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Find out how Synhydrid® is able to replace other metal hydride agents like Sodium Borohydride with greater safety and more selective reductions.

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